This prescribe d elective course aims to deepen your understanding on two major biomedical applications of materials. The course will equip you with the basic principles of drug delivery and tissue engineering and the important roles pla yed by biomaterials in these appli cations. It also presents engineering analyses of drug delivery along with biological and materials aspects of tissue engineering. All of this knowledge is essential for students who wish to specialize in medical materials or pursue a career in the fields of drug delivery or tissue engineering.

By the end of the course, you should be able to:

1. Define drug delivery, controlled release and targe ted delivery
2. Compare and contrast the advantag es and limitations of various drug delivery routes
3. Illustrate the critical roles of polymers in drug delivery systems
4. Explain the mechanisms and roles of materials in diffusion -controlled systems, osmotic -controlled and degradation -controlled drug delivery systems
5. Distinguish zero -order re lease from first -order release kinetics
6. Estimate the drug release rate from diffusio n-controlled, osmotic -controlled and degradation -controlled drug delivery system
7. Explain the mechanism and roles of materials in stimuli -responsive drug delivery systems
8. Explain the principles of passive and active targeting in targeted delivery
9. Define tis sue engineering and its contribution in regenerative medicine
10. Describe the three main pillars that contribute to a successful tissue engin eered product
11. Compare and contrast the advantages and limitation of various cell sources for tissue engineering applic ations
12. Analyze the major building blocks of extra -cellular matrix (ECM) and its functions as nature’s scaffold
13. Explain the basic considera tions in design and materials sele ction for biomaterial scaffolds
14. Describe various common scaffold fabrication methods
15. Recognize different environmental factors (bioreactors and signalling) that affect tissue engineering

• Fundamentals of drug delivery

• Controlled and targ eted delivery

• Principles of tissue engineering

• Biomaterial substrates for tissue engineering

-Treatise on Controlled Drug Delivery, A.Kydonieus, Editor. Marcel Dekker, 1992.

-Biomaterials Science, An Introduction to Materials in Medicine, B.D. Ratner, A.S.Hoffman, F.J. Schoen, J.E. Lemons, 3rd Edition, Academic Press, 2013

-Handbook of Pharmaceutical Controlled Release Technology, D.L. Wise, 1st Edition,CRC Press, 2000.

-Principles of Tissue Engineering, R.P.Lanza, R.Langer, J.Vacanti, Editors, 4th Edition,Academic Press, 2014.

-Biomaterials for Tissue Engineering Applications,J.A. Budrick, R.L.Mauck, Editors.Springer-Verlag, 2011.

-Bioreactor Systems for Tissue Engineering, T. Scheper, C. Kasper, M.Van-Griensven,R. Pörtner, Editors. Springer-Verlag, 2009.